Vitamin K1 25mg Chewable TabletsPhytonadione
Vitamin K1 25mg Tablets are beef-flavored
chewable tablets of phytonadione for use in cats and dogs to counter
hypoprothrombinemia induced by digestion of coumarin-based compounds, common
ingredients of commercial rodenticides (like D-Con), and other drug-induced
hypoprothrombinemia where it is definitely shown that the result is due to
interference with Vitamin K metabolism (e.g., salicylates). Recommended for use
in follow-up therapy only after administration of Vitamin K1 Injection and
hospitalization is no longer required.
Vitamin K1 Chewable Tablets for oral
administration possess the same type and degree of activity as does
naturally occurring Vitamin K. The primary function of Vitamin K is to
stimulate the production via the liver of active prothrombin from a
precursor protein. The mechanism by which Vitamin K promotes formation of
prothrombin at the molecular level has not been established.
DOSAGE AND ADMINISTRATION: Dogs and Cats
Hypoprothrombinemia (with hemorrhage)-Administer
orally at the rate of 2.5-5 mg/kg of body weight (1 tablet per each 22
pounds of body weight for lower dosage or 1 tablet per each 11 pounds of
body weight for higher dosage) daily as conditions require up to 3 weeks.
Frequency and amount of oral administration should be guided by regular
determination of prothrombin time. The smallest effective dose should be
sought to minimize the risk of adverse reactions.
Each beef-flavored chewable tablet contains 25 mg of phytonadione.
Regular determinations of prothrombin time response should be performed to guide in the initial and subsequent administration of Vitamin K1 Chewable Tablets. The dosage should be adjusted accordingly.
Contraindication: Hypersensitivity to any component of this medication.
Vitamin K1 is available in two strengths:
- Vitamin K1 25 mg, for cats and dogs that weigh 11-22 lbs.
- Vitamin K1 50 mg, for dogs that weigh more than 22 lbs.
WARNINGS: It is recommended that Vitamin K1
Chewable Tablets be used in follow-up therapy only after administration of
Vitamin K1 Injection and hospitalization is no longer required. An immediate
coagulant effect should not be expected after administration of phytonadione
when administered orally. Phytonadione will not counteract the anticoagulant
action of heparin. Repeated large doses of Vitamin K1 are not warranted in
hepatic disease if the response to the initial therapy is unsatisfactory.
Failure to respond to Vitamin K1 may indicate that the condition being
treated is inherently unresponsive to Vitamin K1.
PRECAUTIONS: Patient may develop temporary
resistance to prothrombin-depressing anticoagulants, especially when given
larger doses of phytonadione.
Vitamin K1 Chewable Tablets are sold
only to licensed veterinarians.
Protect product from
light at all times. Keep out of reach of children. Store at room
Supplied as Vitamin K1 Chewable Tablets are
available in bottles of 50 Chewable Tablets.
FOR ANIMAL USE ONLY
KEEP OUT OF REACH OF CHILDREN